Abstract
We examined bio-compatibility, solute removal efficiency, U. F. R. and SEM observation of a surface-modified regenerated cellulose membrane dialyzer, which is modified by attaching Vitamin E to increase its bin-compatibility (CL-E-15N; hereafter called E-membrane; made by Termo Co.), comparing with conventional dialyzer (CL-S-15N; hereafter called S-membrane).Bio-compatibility: the changes of leucocytes, C3a and oxidized LDL in E-membrane were significantly lower- than those in S-membrane, and the changes of platelets, TAT, t-PA, G-E and MDA were not different between E-membrane and S-membrane. Solute removal efficiency: removal rate, removal quantity and clearance were not different between E-membrane and S-membrane. U. F. R., in E-membrane was higher than that in S-membrane, and was not decreased during hemodialysis. SEM observation: a platelet agglutination on E-membrane was lesser than that on S-membrane and most of the platelets retained a spherical shape on E-membrane, clot and pseudopod were observedon S-membrane From the these results, it was concluded that CL-E-15N had similar solute removal efficiency and better bio-compatibility than conventional regenerated cellulose membrane.
