Abstract
Secondary vascular impairments arefrequently observed among diabetic patients. It is considered that thereason of the impairments is theexistence of glycosylated compounds, especially glycosylated LDL. (glc-LDL) Newly designedadsorbents were synthesized and prepared aimingfor aselectiveremoval of glc LDLfrom human plasma The adsorbentshad two moieties for glc LDL, one is boronicacid for glycosylatedsites of glc-LDL, the otheris acrylicacid (AA) for positivecharge of apoprotein. The adsorbents weree valuated interms of glc-LDL adsorption efficiency in human plasma, and showed different characteristics depending on the polymer compositions. The AA compositions from 50 to 90% showed highselectivities for glc-LDL. The selectiveadsor ptions of glc-LDL were not inhibited in human plasma The sere sults suggested that the adsor bents would be promising materials for glc-LDL apheresis.
