Abstract
We report the efficacy of artificial pancreas for the evaluation of glucose metabolism and blood glucose control of the severely ill patients. 11 patients was studied. The items studied as indicators of glucose intolerance were, (1) daily mean blood glucose level (BSm), (2) I/E (administered insulin/glucose) ratio, and (3) M-value (glucose disposal rate) obtained from euglycemic hyperinsulinemic glucose clamp method. [RESULTS] 1) Blood glucose control by artificial pancreas was good, because mean value of BSm was 169.4±28.6mg/dl. 2) There were 4 types of the improvement of glucose intolerance. Both (1) [M-value] and (2) [insulin secretion (CPR)] increased in cases without complication, (1) increased mainly in cases with DM, (2) increased mainly in cases with liver cirrhosis, and (3) [hepatic glucose production] supposedly decreased in cases with liver dysfunction. [SUMMARY] Application of artificial pancreas to severely ill patients with glucose intolerance was effective for the evaluation and treatment of impaired glucose metabolism.
