Abstract
The clinical study was performed to evaluate the biocompatibility of heparin-coated bypass circuits. Ten patients undergoing elective cardiac surgery of valve replacement were randomly divided into two groups with (group H, n=5) or without(group C, n=5) use of heparin-coated circuits. Interleukin 1 & (IL-1 &), Interleukin 6(IL-6), Granulocyte elastase (GEL), C-reactive protein and Fibronectin (FN) were mesured before cardio-pulmonary bypass (CPB), 60 minutes after commencement of CPB, 60, 240, 480 minutes after termination of CPB, on the first, the third and the seventh postoperative days respectively. Respiratory Index (RI) was mesured before and immediately after CPB, on the first postoperative day. IL-1 & was not detected except one case in group C. IL-6 increased after CPB in both groups, but the response was significantly low in group H (P<0.05). CRP and GEL were increased after CPB in both groups, but showed no significant difference between the groups. FN recovered quickly after CPB in group H with a significant difference (p<0.05). RI increased after CPB in both groups, but tended to be lower in group H than in group C (p=0.05). This study demonstrated that the use of heparin-coated bypass circuits improved the biocompatibility by reducing the level of inflammatory cytokine and the pulmonary injury.
