Abstract
A closed circuit system coated with MPC (2-methacryloyloxyethyl phosphorylcholine) copolymer was filled with 150ml human whole blood. Platelet count, platelet adhesion, platelet agguregability and serum complement activity were measured during the circulation for 2 hours by a 30ml/min flow rate. A system without coating was used as a control. After circulation, total amount of protein adhered on the Iuminal surface of the system was measured. Luminal surface of the system after circulation was observed by means of a scanning electron microscope. Total protein adhered was less, platelet adhesion was kept and complement activity was reduced, compared with those of the control. These results indicated that a blood circuit system coated with MPC copolymer maintained platelet adhesion and reduced complement activation.
