Abstract
Solute removal characteristics in Push/Pull HDF were examined during an experimental study and an analytical study. Three types of experiments were carried out: (a) traditional HDF (Steady-state), (b) Push/Pull HDF (Unsteady-state) and (c) step change from HD to Push/Pull HDF (Step response). And an out-put response method was applied for (b) and (c). From the results in (a) and (b), Push/Pull HDF has a lower efficiency of urea removal than that in HD and a higher myoglobin removal. Out-put response in solute concentration at blood side clarifies an effect of unsteady-state in Push/Pull HDF. Value for time-averaged myoglobin clearance increased with higher filtration flow rates in both Pull and Push phases, and dialysate reservoir volume. Optimum operating condition, however, should be taken account of patient's safety.
