THE CLINICAL APPLICATION OF CLOSED-LOOP SUBCUTANEOUS INSULIN INFUSION ALGORITHM WITH SHORT-ACTING INSULIN ANALOGUE FOR WEARABLE ARTIFICIAL ENDOCRINE PANCREAS

Abstract

For long-term clinical application of the wearable artificial endocrine pancreas, closed-loop subcutaneous insulin infusion algorithm has been developed by analyzing the kinetics of subcutaneous absorption of Insulin Lispro which was absorbed 2 to 3 times faster after subcutaneous injection than usual regular insulin. By applying this algorithm, blood glucose and plasma insulin responses to oral glucose load or dally glycemic excursions were similar to that with intravenous insulin infusion algorithm without showing any delayed hyperinsulinemia nor hypoglycemia. These data indicated feasibility of lone-term glycemic control in dabetic patients with closed-loop subcutaneous insulin infusion by the wearable artificial endocrine pancreas.