Abstract
In ten patients with acute pancreatitis, metabolic rate, organ failure (MOFscore), pancreatic enzyme, and glucose tolerance (administered insulin/glucose (energy) ratio: I/E ratio) were studied as well as triglyceride (TG) and free fatty acid (FFA). 1) Although glucose intolerance was severe (mean of I/E ratio was 78.1±41.5mIU/kcal), blood glucose (BG) was well controled (daily mean BG was 179.9±25.4mg/dl). This strict BG control was essential for the following results because serum TG and FFA are greatly influenced by BG. 2) There was negative relatioship between BEE and TG. 3) TG increased with the progress of MOF (mean of TG in patients with MOFscore between Oand 2, 3 and 5, and more than 6, was 105±30.1, 142.5±44.2, and 149.2±49.1 mg/dl, respectively). 4)Mean of TG in patients with serum amylase (AMY) more than 1000IU/L was significantly smaller than that in patients with AMY less than 1000IU/L. 5) FFA increased as I/E ratio increased. It seemed that hypermetabolism, organ failure and pancreatic enzyme influenced TG utilization by peripheral tissue, TG production by liver and TG resolution. There was close relationship between FFA and glucose intolerance. Artificial pancreas was useful not only for BG control, but also for the evaluation of fat metabolism.
