Abstract
During extracorporeal circulation, it has been thought that the hemolysis is caused by chemical and physical actions. There occur various forms of flow inside of the blood circuit and artificial organs. We think that the main factors which cause the hemolysis are physical factors, for example surface roughness, velocity gradient, pressure and temperature. Then, we investigated about the effects of physical factors and the complex effects of physical factors on hemolysis. In the experiments, bovine blood has been used with anticoagulant. As the result of that, we had a small amount of hemolysis about the factors of surface roughness, velocity gradient, pressure, temperature. On the other hand, we have confirmed that the complex effect has an influence on hemolysis. Especially, when the velocity gradient and pressure factor or temperature factor are addedto the blood at the same time, there occurs a higher amount of hemolysis than the single effect of a physical factor. However, it is thought that a collision stream causes hemolysis. In conclusion, we considered that it is possible to reduce the hemolysis when we could know the size of physical factors inside of the blood circuit in various conditions.
