Abstract
To assess the biocompatibility of heparin-coated cardopulmonary circuits using Capiox SX, filters and tubing sets (TERUMO. CO.), we had measured as follows in group H (using heparin-coated circuits, n=9) and in group C (using ordinary circuits, control group, n=9). Compliments (C3a, C4a), granurocyte elastase (GEL), cytokines (Interleukin 6 & 8), Tumor Necrosis factor (TNF), thrombin-antithrombin III complex (TAT), fibrinopeptide A (FPA), fibrinogen, antithrombin-III (AT-III ), D-dimer, a 2-PI, renal function, liver function were measured before, during and immediately after cardio-pulmonary bypass (CPB), 24 hours after CPB (24H), and on the third operative day (3D), No statistically significant changes were found in all factors between the two groups. But peak levels of IL-6, C3a and GEL at AF in group H were lower than in group C. Furthermore, D-dimer reached its maximum value at AF in group C, but at 24H in group H. This study demonstrates the tendancy that the use of heparin-coated circuits reduce the release of IL-6, C3a, GEL and D- dimer, but the method of evaluation of organ damages should be reconsidered.
