LONG-TERM CLINICAL APPLICATION OF WEARABLE ARTIFICIAL ENDOCRINE PANCREAS WITH CLOSEDLOOP SUBCUTANEOUS INSULIN INFUSION ALGORITHM USING SHORT-ACTING INSULIN ANALOGUE.

Abstract

For long-term clinical application of the wearable artificial endocrine pancreas, closed-loop subcutaneous insulin infusion algorithm has been developed by analyzing the kinetics of subcutaneous absorption of Insulin Lispro which was absorbed 2 to 3 times faster after subcutaneous injection than usual regular insulin. The wearable artificial endocrine pancreas with this algorithm was applied to control daily glycemic excursion in diabetic patients. Near-physiological glycemic controls for up to 7 days were obtained with this system. These data indicated feasibility of long-term glycemic control in diabetic patients with closed-loop subcutaneous insulin infusion by the wearable artificial endocrine pancreas.