Abstract
As alternative and a sophisticated way of glucose monitoring system, the development of non-invasive glucose monitoring system has been expected. We have examined the possibility of non-invasive glucose measurement by using Fourier transform infra-red spectroscopy with attenuated total reflection (ATR) prism. 1. Glucose has characteristic absorbance at the wave numbers of 1033 and 1080 cm-1, and the absorption intensities are proportional to glucose concentrations. 2. Glucose concentrations in the serum and whole blood samples could be measured quantitatively, if the base-line drifts and interferences other than glucose were subtracted, by expressing as the difference absorbance with the spectrum of fasting sample, as an individual characteristic. 3. With an application of calibration algorithm or the Chalcogenide optical fiber system to adjust the spectral changes due to the attachment pressure of ATR prism to mucous membrane, submucosal tissue glucose concentrations could be measured or monitored continuously by analyzing absorbance spectra through mucous membrane of lip. Although the improvement and further developments of the system in both hard-ware and soft-ware basis in order to improve measuring sensitivity should be necessary, the non-invasive glucose monitoring system will be available in the near future.
