Abstract
A newly developed novel method for controlling blood glucose is compared with the model predictive controller under continuous glucose infusion. (Method) Continu ous intravenous glucose infusion at rates of 50, 100, and 200mg/kg/h was conducted on pancreatectomized dogs. A new blood glucose control method using a combination of the proportional controller in the initial stage and the model predictive controller in the later stage was compared with the model predictive controller. The parameters of the novel controller were determined from identification of individual responses to the infused insulin during the first 60 min. The parameter of the proportional controller was changed at 60, 90, and 120min, so as to reflect the response to infused insulin. (Results) The model predictive controller could reach the target level in the usual manner at the low infusion rate of glucose. However, under glucose infusion rates of 100mg/kg/h and more, it was difficult to reach the target level within 8 hours. In contrast, the novel controller could reach the target level in 5 to 8 hours. (Conclusion) Addition of the modified proportional controller to the model predictive controller can stabilize the blood glucose control under continuous glucose infusion.
