This study has been undertaken to examine the possibility that permeability of dialysis membrane may be improved by adding CDP-cholin and antibiotics to dialysate.
One liter of ultrafiltrate obtained from uremic patients is used as blood and recirculated at a flow rate of 200 ml/min and 1 liter of commercial dialysate is used as dialysate and recirculated at 500ml/min. Twenty-six grams of activated charcoal, 500mg of of baramycin, lg of streptomycin, 100mg of enramycin and 500mg of CDP-cholin are added to the dialysate and dialysances for urea, creatinine and others are obtained.
Urea dialysance is 80ml/min without any additives. Urea dialysance is 83ml/min when activated charcoal is added and it increases to 95ml/min by adding ac ivated charcoal and baramycin. With activated charcoal and streptomycin, -dialysance increase to 100ml/min, and to 110ml/min when activated charcoal and enramycin are added. When CDP-cholin is added, it increases to 125 ml/min. Creatinine dialysance is 64ml/min whithout any additives, but is 68ml/min with activated charcoal, 73 ml/min with activated charcoal and baramycin, 77ml/ min with activated charcoal and streptomycin, 80ml/min with activated charcoal and enramycin, and 85ml/min with CDP-cholin.
There is a possibility that actiavted charcoal CDP-cholin and some antibiotics might enhance transportation of substances through dialysis membrane and dialysance for various substances are increased.
