抄録
A new assisted artificial liver with compulsory electrodialysis was developed to remove rapidly the toxic substances, especially of ammonia or lower fatty acid, which is considered as one of pathogenesis of hepatic coma. An assisted artificial liver devised by us consists of both electrodialyzer and metabolic perfusion circuit. The membranes of CMV and AMV as blood dialyzer were used and electrified between them. By reforming these membranes, blood dialysis could be applied to both ACC and AC method. The effects on blood dialysis were quantitatively analysed by in vitro and in vivo experiments. With increasing electrical current and effective dialysis area, the rapidity and efficiency of blood ammonia removal was increased, which was analytical showed by graphycal representation. Furthermore hemolysis and denaturation of protein by the electrodialyzer was quantitatively discussed with liver failure dogs made by portacaval shunt subsequently with ligation of hepatic artery. From these results it was discussed that the AC method was available in practical use. Electrodialytic disposal of amino acids or amines in addition to ammonia is now investigated and reported in detail hereafter.
