抄録
Polyvinyl chloride (PVC) materials are widely used in medical and paramedical applications for their excellent mechanical properties and ease of molding and fabrication, however their safety is controversial. Simple in vitro evaluation methods are proposed to select safer PVC materials and devices. Test samples of the same sheet size were extracted in distilled water at 37° or 70°C The eluates obtained were analyzed spectrophotometrically and the absorbance of ultraviolet absorption at 220nm was measured. The elution was followed with time and elution (or absorbance) -time curve was obtained. After appropriate time of extraction. all the eluates were discarded, water was renewed. and the extraction was continued further This repeated extraction test gave an important criter on as to the persistency of elution of the leaching substances. Rate and tterststencv of elution, and amount of leachable substances were determined. Hemolysis test was performed by direct contact of the tes samples with red blood cell.
Commercial medical PVC tubings, administration set and blood bags were compared, and found to show different elution characteristics and hemolysis rate. It is recommended to use the PVC materials or device which show low degree of elution and hemolysis.
