Experimental studies of the modified human umbilical cord vein graft

Abstract

Gluteraldehyde was applied to archieve sustained host tolerance maintenance of vascular function and suppression of antigenicity by chemical treatment of human umbilical cord vein.
Gluteraldehyde showed very strong bacteriocidal effect by our sterilization test.
The antibody product after transplantation of the modified human umbilical cord vein graft on to canine inferior vena cava was not detected by the method of complement dependent cytotoxi city test.
The content of mucopolysaccharides extracted from this graft was between canine thoracic aorta and inferior vena cave.
(Uroni c acid: 4.7 μ mole/g dry weight, Hexosamine: 4.8 μ mole/g dry weight and N-Sulfate: 1.2 μ mole/g dry weight)
We thoght this mucopolysaccharides to play the important role of antithrombogenicity of the inner surface of the graft.