Natural history of ventricular septal defect (VSD) due to acute myocardial infarction (AMI) is very poor. To decrease the mortality rate in those severe patients, we have attempted IABP in dogs associated with VSD or VSD c AMI which was produced by ligation of the left anterior descending coronary artery. And hemodynamic studies were done in detail.
In this study all.dogs were divided into S groups such as group 1:QP/QS 1.0-2.5, group 2:QP/QS 2.5-4.5, group 3:QP/QS over 4.50. Hemodynamic changes due to IABP were evaluated from the degree of QP/QS above described. Consequently, the best result of effects of IABP was recognized in Group 2. No effect of IABP could be obtained in Group 3 indicated more than 4.5.
