Insulin therapy is now the only active and effective treatment for diabetic patients. Although it is difficult to regulate blood glucose into the narrow physiological range by conventional administration of drugs, ideal metabolic control should be developed.
We are trying to synthetize an control system of blood glucose and to establish the artificial beta cell; a glucose sensor continuously measures the blood glucose level and this information feeds into a micro computer which energizes an infusion pump, and controlled amounts of insulin from a small resorvoir enter into the diabetic's circulation.
In this study, the quadratic linearized model is employed as the mathematical model for the blood glucose regulatory system, and the modern control theory is applied. At present, this system has been developed as a bedsidee apparatus for the clinical treatment for hospitalized patients.
