MOUSE PERITONEAL MACROPHAGE REACTION TO GUTTA PERCRA

抄録

Mouse peritoneal macrophages were reacted with gutta percha, a kind of natural rubber which widely used as the root cannal filling materials in endodontic therapy. Fine gutta percha particles were phagocytized by mouse macrophages in vitro. Intraperitoneally injected gutta percha particles stimulated peritoneal macrophages and accumulated in milky spot on the omentum. Intraperitoneally implanted pure gutta percha membranes were covered and penetrated by macrophages. Clinically used gutta percha membranes were digested partialy in the same enviroment. Thus, the evidence has been obtained that gutta percha is not biologically inert in strict sense, but induce the defence reactions in the doby.