A new antithrombogenic elastomer (H-USD) has been developed by heparinizing the blend polymer (USD+) composed of segmented polyurethane (U) and cationic hydrophilic crosslinkable terpolymer (SD+).
The relationship between higher order structure of USD+ or H-USD and their antithrombogenicity was studied. Moderate phase separation of blend polymer was found to be necessary for antithrombogenicity owing to their effective heparin absorption and elution.
The degree of phase separation was controlled by changing the blend ratio of U and SD+, then the optimum blend ratio for both antithrombogenicity and mechanical strength was determined.
