Since 1972, we have been used Membrane Oxygenator for open heart surgery. Recentry 500 cases, Kolobow Spiral Coil Membrane Oxgenator have been used. 0.8sq.M. oxygenator was used in 58 cases, 1.5sq.M. in 117 cases, 2.5sq.M. in 65 cases, 3.5sq.M. in 233 cases and 4.5sq.M. in 27 cases. Max, blood flow of each oxygenator was 600ml/min. at 0.8sq.M. lung, 1.51/min. at 1.5sq.M., 2.51/min. at 2.5sq.M., 4.01/min. at 3.5sq.M., and 5.51/min. at 4.5sq.M.. And rated gas flow was 1.0-2.0 of V/Q. and 50% of FiO2.