The dynamic property of glucose-induced insulin secretion was simulated with control theory, and the relationship between glucose concentration and insulin secretion was expressed in the transfer function of proportional plus derivative action to glucose concentration.
By utilizing this system, the computer algorithm for the artificial beta cell was made.
Microcomputer, insulin pump, and glucose analyzer were packed compactly in the size of 35cm W×25cm D×16cm H for bed-side use.
The characteristics of the system recognized in clinical applications were; 1) Rate of insulin infusion was small enough to keep the plasma concentration of insulin physiological, then insulin requirements were reduced to around a half of those given subcutaneously, 2) Glucose or glucagon to restore hypoglycemia was not necessarily needed.
