Recently, the assisted extracoporeal circulation (AEC) is performed in clinics whereas survival rate of patients is unfortunately very low.
Using 6 anesthetized dogs, AEC (mean flow, 50ml/kg/min) experiments were done during 12 23hr (mean 18hr) and 2 dogs survived more than 3 days after the weaning of the AEC and 4 dogs died within 2 or 3 hours later of the weaning. In both survival and dead groups, P and Q decreased, V and P increased, P and PaO decreased and PaCO increased just immediate after begining of AEC, and the survival group showed less changes of these measurements than the dead group. During PaO decrease and increase of PaCO and PaCO -P were continuously observed in both groups. Six hours later of the bigining of AEC, D increased about 83% of control and this phenomenon suspected pulmonary congestion.
In survived 2 dogs, P changed gradually. Rapid and huge changes of P appeared in dead group. The meaning of this difference of P between survival and dead group is very important. Extreme changes of P may induce pulmonary damages.
In order to use of AEC on pulmonary diseases patients, of P should be kept at constant value and we must aboid extreme changes of P as possible as we can.
