Abstract
Mitomycin C (MMC), a potent anticancer drug, was microencapsulated with ethylcellulose based on the principles of coace rvation with certain modifications. The mean particle size was 224μm, so that the capsules were readily infused through an 18-G needle and the capsules contained 80% (W/W) of biologically active MMC on average. Sustained-release of MMC from the capsules was demonstrated by in vitro and in vivo experiments. Selective intra-arterial infusion of the capsules into dog kidneys resulted in persistent activity of MMC in the organ and decreased release of MMC into circulating blood. Mitomycin C-microcapsule could be applied to an intensive cancer chemotherapy with minimum side effects.
