FILTRATATE REGENERATION SYSTEM IN HEMOFILTRATION

抄録

It is possible to approach further towards an ideal artifical kidney by combination of the hemofiltration with reabsorption system of water and essential solutes from the filtrate. The purpose of this study is to develop filtrate regeneration system in the hemofiltration. The filtrate of the hemofiltration was treated with three different regeneration devices: activated charcoal, standard REDY sorbent system and standard REDY sorbent system plus reverse osmosis process. Extraction of solutes such as waste substances and electrolytes by the regeneration device was measured by means of chemical assays and chromatography analyses. Activated charcoal sufficiently cleared creatinine, uric acid and guanidine derivatives but not urea in the filtrate. Electrolytes unbalance and metabolic acidosis were not improved and compensated by activated charcoal only.
Standard REDY sorbent cartridge was capable of removing almost all metabolic wastes and inorganic phosphate as well as calcium and magnesium. NaCl concentration in the regenerated filtrate was increased by REDY system. Supplement of calcium and magnesium was required and sodium chloride should be eliminated by small quantity, when the regenerated filtrate was used as substitution fluid. To prevent bacterial and endotoxin contaminations and elevation of NaCl concentration in the regenerated filtrate with REDY system, combination of R-O process and electrolytes proportion system with REDY system makes better regeneration of the filtrate. Further developments and investigations are necessary to improve performance of the filtrate regeneration system and for clinical application.