Extracorporeal circulation has been considered to be a kind of controlled shock state. It would be reasonable that remarkable hypoperfusion to abdominal region leads to ischemic changes of the tissues, finally causing of organ failure.
We have prophylactically used phnoxybenzamin (POB), that is α-Blocker, in clinical cases and obtained satisfactory results of open heart surgery. While, in hemorrhagic shock model used with adult mongrels, the lysosomal enzyme release into blood was obviously suppressed if POB administered prophylactically, and in this study, we observed by electron microscopy that cell damadages of liver and pancreas were remarkably reduced in cases of POB administration.
