An attempt to prevent hemolysis during extracorporeal circulation was made using Poloxamer 188 (Px) in open heart surgery. In this study, 21 out of 30 cases were given 1mg/ml of perfusate and the remaining nine cases were served for control.
Elevation of serum hemoglobin (S-Hb) level was observed in both groups during extracorporeal circulation with a lesser inclination of elevation in Px group (p<0.05). At the end of the bypass, S-Hb level in Px group was significantly low of 0.30 compared to control of 0.63mg/dl/min (p<0.005).
These data support clinical use of Px which protects blood cell destruction during extracorporeal circulation without remarkable side effect.
