A new approach to treat the patients with Systemic Lupus Erythematosus was descrived
In place of plasma exchange, we tried to remove specifically the pathogenic substance circulating in the vessels of the patients, that is, immune complexes, anti DNA antibody, DNA and DNA-anti DNA complex.
125I Human serum albumin (HSA)-anti HSA complex was adsorbed on Clq-sepharose 4B.
Anti DNA antibody in serum was removed with DNA cellulose column. 125I DNA and soluble 125I DNA-anti DNA cmplex in serum were efficiently removed with the methylated albumin-sepharose column.
