Abstract
In vivo experiments of direct hemoperfusion were performed on acute kidney insufficient dogs using the adsorbents Amberlite XAD-4, Amberlite XAD-2 and Pamead.
The following results have been obtained from the above mentioned experiments:
There is no hemolysis in Amberlite XAD-2 or XAD-4 without coating. However, in Pamead, a great deal of hemolysis and clotting occurs in the same condition. BUN is not adsorbed by all of the adsorbents. On the other hand, in Pamead only 6% of creatinine is adsorbed per hour. Furthermore, the adsorbent efficiency of uric acid is 29.1% in Amberlite XAD-2, 40.6% in Amberlite XAD-4 and in Pamead. No electrolytical imbalance has been shown in XAD-4. But there in a 4% decrease of calcium found in Pamead and a Potassium decrease of 12% found in Amberlite XAD-2. Also, we can see pancytopenia in all kinds of adsorbents, especially in Pamead. Whereas Amberlite XAD-2 shows a 59% decrease of platelets, Amberlite XAD-4 shows a decrease of less than 32%. Pamead shows only clotting, so we can't use it without using the coating.
To conclude, we can generally obtain good in vivo results in Amberlite XAD-4, if consider the clinical use of Amberlite XAD-4 without coating.
