A hemofiltration is used in therapy of uremia. This method is also possible to be used in therapy of hepatic failure. We developed handy type hemofiltration and plasma exchang machine. This machine has two roller pumps; one is a three tubed roller pump, and the other a small one tubed pump. In order to make drainage and return blood flow rate equal, two of the three tubes are used for drainage and return blood pump, and third is used for negative pressure pump. Inlet of substitute is connected between filter and return tube. Therefore, the substitute is infused with a same volume of ultrafiltrate without special device. In order to correct hypervolemia, the small one tubed pump is used in parallel with drainage pump; thus, make a difference of flow rate between drainage and return. Adoption of these methods enable to develop the handy type.
