抄録
Experimental examination of Human Umbilical Cord Veins (H-UCV) as a vascular substitute was started at 1969 in our department. Since 1975, clinical applications of Glutaraldehyde (GA)-tanned H-UCV as a arterial substitute are going on.
41 peripheral arterial vascular reconstructions, in 39 patients, were performed. Up to date it's cumulative patency rate is 92.6% at one year, 88.2% at two years and 81.9% at 3 and 4 years.
On the other hand, since 1977, Equine Umbilical Cord Vessels (E-UCV) were investigated as a larger sized material than 6mm in diameter.
Fundamental evaluation demonstrated it's many good points, that is optimal elasticity, high tolerance to inner pressure, good antithrombogenicity and large caliber.
As a vascular substitute, especially as a venous substitute, GA-tanned E-UCV transplantations into venous system have been studied.
Antigenicity of H-UCV and E-UCV was evaluated with delayed hypersensitivity skin reaction, which reflects cell-mediate immunity well and lyphocyte blast transformation. It was revealed that antigenicity of H-UCV and E-UCV was gratifyingly suppressed by GA-tanning.
Results of immunological examinations and GA-tanned E-UCV transplantations for venous reconstruction of mongrel dogs are presented in this paper.
