抄録
Recently we performed exchange transfusion (E. T.) and charcoal hemoperfusion (H. P.) on four cases of hepatic coma encountered by us and made a clinical study on E. T. ana H. P. They consisted of fulminant hepatitis three cases and one case of rapture of esophageal varix due to liver cirrhosis, there being one case on E. T., and two cases on H. P. and one case on the combination of E. T. and H. P. A comparative study was made on the clinicalbiochemical effect before and after E. T. and H. P. performed on these four cases to reach a conclusion as follows:
(1) It is unlikely that NH3 could be eliminated to such an extent as is concerned with the recovery of consciousness following E. T. and H. P.
(2) As for methionine, phenylalanine, tyrosine and tryptophane of which values had hitherto been considered high it hepatic coma, they showed no relation with level of consciousness.
(3) It is presumed that not single substance but two or more substance other than the one hitherto mentioned will be concerned with the disturbance of consciousness.
