In order to develop the designed materials for artificial organs, the interaction between materials and biological system should be clarified. In this report the problem about protein-adsorption on the surface of artificial organ was described from the view point of the functional change of adsorbed plasma proteins. The results of conformational analysis of serum albumin and γ-globulin adsorbed on polyion complex (PIC) corresponded to those of platelet adhesion behavior on PIC. The conformational change (denaturation) of adsorbed albumin contributed to enhance the adhesion and metamorphosis of attatched platelets. The orientation of adsorbed γ-globulin turned out to play an important role on the adhesion of such cells as platelet, leukocyle and lymphocyte.
