抄録
Avcothane coated PVC paste (Av-PVC) pump have made prolong the survival days of goats replaced totally with artificial heart and made improve the animal's surviving condition in our institute. In this study, the Av-PVC pump antithrombogenecity was compared with that of PVC pastepump and segmented polyurethane by SEM analysis. The effect of anticoagulant, anti-platelet aggregate drug and the influence of blood flow rate on these material antithrombogenecity were also investigated. The Avcothane surface was almost free from platelet or fibrin deposition after use in animal for few months under the use of anticoagulant. In the case without use of heparine, a small amount of micro-fibrin deposition was observed on the Avcothane surface. Platelet deposition on the PVC paste surface was comparatively little, in spite of thick protein layer deposition. Polyurethane used inthis study revealed almost the same antithrombogenecity with Avcothane.
