Research and development of the plasma molecular/gene introduction method and its future

抄録

This paper describes the plasma gene/molecule transfection method, which led to the device’s launch at the end of 2024. Plasma induces endocytosis, the cells' spontaneous uptake of external molecules through combined electrical and chemical stimuli. Since the combined stimuli induce spontaneous uptake of molecules by the cells, the intensity of each stimulus can be weak, thereby suppressing damage to the cells. Furthermore, the micro-plasma method can introduce large molecules, such as plasmid DNA, without causing random genome integration. This is effective as a practical means of introducing genes and molecules with a view to medical applications and is expected to be a valuable tool for genome editing.