Pathogenesis of Shigella: the study of bacteria-host interplay at the intestinal mucosal barriers

Abstract

Shigella are capable of invading and colonizing the intestinal epithelium, which results in strong inflammatory colitis. Shigella deliver a subset of effectors via the type III secretion system during infection into host cells. The delivered effectors mimic and usurp the host cellular functions, and modulate host cell signaling and immune response, thus playing pivotal roles in promoting the bacterial infection and circumventing host defense systems. This article overviews the characteristics of pathogenesis of Shigella, and highlights current topics related to the roles of the effectors in promoting bacterial infection.