Production and biological activity of the triazine derivatives: focusing on antibiotics produced by bacteria

Abstract

Heterocyclic triazines and their derivatives have excellent biological activity and have been used as herbicides and anticancer drugs. A large number of derivatives were synthesized and their biological activity was investigated. Some bacteria synthesize the triazine derivatives such as Nostocine A, Toxoflavin, and Fluviol from GTP using enzymes similar to those in the synthesis pathway of Riboflavin (vitamin B2). These triazine derivatives show antibiotic activity. In particular, research on Toxoflavin has progressed as a toxin produced by bacteria that cause seedling rot and rice grain blight in rice. It has recently been revealed that Fluviol, which is produced by bacteria, acts to suppress the growth of pathogenic bacteria. This review will focus on triazine derivatives produced by bacteria.