抄録
Effects of a new trichomonacide TRICHOFURON (Yamanouchi Co.), which is contained furazolidone and nifuroxime, upon the growth of T. vaginalis in vitro and in vivo were evaluated in the present studies. For in vitro studies, two strains of T. vaginalis which were maintained in cystein-bouillon-serum medium without accompanying bacteria were used. Chemically pure furazolidone was added into the medium in various concentrations, ranging from 10-2mg per ml to 10-5mg per ml. Complete inhibitory concentration of furazolidone for the growth of T. vaginalis was determined to be 0.002mg per ml. Growth of the organism was slightly inhibited at the concentration of 0.1γper ml. Besides furazolidone, nifuroxime which was said to be potent fungicide showed relatively strong inhibitory action on the growth of T. vaginalis. T. vaginalis infection in sexually mature female rats which were injected estradiole prior to the inoculation of the organism into vaginae was used for in vivo experiments. Suppository of trichofuron was introduced into vaginae of rats for successive ten days. By this treatment, T. vaginalis infection in rat vaginae was not cured completely in all of the cases, though in some cases the organism disappeared temporarily from vaginal discharge of the rats. In clinical experiment, two out of four cases were cured completely by the treatment in which suppository of trichofuron was used for successive 13 and 20 days respectively.
