Studies on the Acetylenic Compounds

Report I. The Antifungal Action of 2, 4, 5-Trichlorophenyl-γ-Iodopropargyl Ether

Abstract

The authors found interesting results on acetylenic compounds by microbial and animal tests, which are described herein.
It is known that same acetylenic compounds such as dicarbamoylacetylen (Collocidin: Lenamycin) and Capillin have antimicrobial activity. During the course of the synthetic study in this laboratory to find those acetylenic compounds with antimicrobial activity, we came to new compounds, halophenyl-γ-iodopropargyl ethers which have very potent activity on fungi and some other microbes. Among these compounds, 2, 4, 5-trichlorophenyl-γ-iodopropargyl ether had each minimal inhibitory concentration of 0.25γ/ml, 0.25γ/ml, 0.78γ/ml against Trichophyton asteroides, T. interdigitale, T. rubrum and also showed rather high activity for other fungi, Cryptococcus, Staphylococcus, Streptococcus, Bacillus subtilis, Mycobacterium in dilution assay.
The high activity of the compound for Trichophyton in vitro was also proved by the curative effects ton infectious animal tests.(guinea-pig)