Abstract
A hypersensitive reaction was observed in three research workers who manage snake venom. Symptoms of those reaction were such as continuous sneezings, serous rhinorrhea, conjunctival itch, dificulty of breething like asthma and general nettle rash. Those hypersensitivity were thought to be induced through inhalation of venom while working in their laboratory. Hypersensitivity appeared within two years in those persons. Steroid, antihistamin and fluid transfusion were effective as treatment.