抗日本脳炎ウイルス血清の2-Mercaptoethanol感受性に関する研究
第5報 ブタ血清のSephadex G-200による分画
1968 年 23 巻 5 号 p. 366-369
詳細
1968 年 23 巻 5 号 p. 366-369
In a series of their previous papers, the authors reported that 2-Mercaptoethanol (2ME)-sensitive antibody against Japanese encephalitis virus had been detected from pigs during the first two to four weeks of antibody response and that, thereafter, the antibody had become resistant to 2ME treatment. Further studies were carried out to characterize the swine antibodies obtained at various stages of antibody response by means of the gel filtration technique using Sephadex G-200. Most of the antibody of initial response was found to be contained in the 19S fraction and to be 2ME-sensitive. From serum samples of a pig which had previonsly been reported to have produced 2ME-sensitive antibody at the third oversummering, the antibody was detected in the 19S fraction. Possibility of reinfection by Japanese encephalitis virus in antibody-bearing pigs and human beings was suggested in relation to antibody response.
