家兎実験梅毒における多重感作実験
ゴム腫生成機転に関する考察
1969 年 24 巻 7 号 p. 345-353
詳細
1969 年 24 巻 7 号 p. 345-353
In experimental syphilis in rabbit, an exudative change which brings about destruction of the site of inoculation may be caused by the antigen-antibody complex.
In this investigation, an immunosuppressive agent was used to control the production of antibody.
On the other hand, multiple sensitization by the Treponema pallidum Nichols strain was repeated.
As a result, a gumma and a granuloma which was likely to change into a gumma were produced. In the central region of the gumma, the presence of Treponema pallidum was proved.
In the sensitized rabbits, serum antibody was measured by VDRL, TPHA, and TPIA. To check the presence of localized antibody, the fluorescein isothiocyanate-labeled antigen technique was applied.
