2019 Volume 10 Issue 2 Pages 106-110
We retrospectively investigated the vancomycin (VCM) prescription, estimated from the pre-calculated clear space ratio of our ICU patients under a sustained high-efficiency daily diafiltration using a mediator-adsorbing membrane (SHEDD-fA). Patients with sepsis who received 1.0 g of vancomycin every 6 hours were analyzed. Median blood concentrations of VCM at 0 hours, 6 hours, and 12 hours were 20.5μg/mL (13.9-22.6) , 18.4μg/mL (17.1-22.3), and 19.7μg/mL (16.4-21.4), respectively. Patients with maintained renal function or dialysis dependency were included in the analysis as it was suggested that estimated VCM prescription during SHEDD-fA could maintain blood concentration at a constant dose regardLess of patients’own residual renal function. This result also applies to the case of hemodiafiltration (HDF) or sustained low-efficiency daily diafiltration (SLEDD) with blood purification equivalent to that of SHEDD-fA.
