An investigation of coagulation/fibrinolysis biomarkers as predictors of circuit coagulation in continuous blood purification therapy

Abstract

In the present study, we identified the predictive biomarkers of circuit coagulation in continuous blood purification therapy, and evaluated the efficacy of our circuit coagulation predictive method during continuous blood purification therapy. Twenty-seven samples were obtained from the patients underwent AN69ST-CHDF for sepsis or septic DIC were examined during the period from April 2017 to January 2018. We divided into two groups (coagulated and non-coagulated groups) depending on the circuit coagulation within twenty-four hours from continuous blood purification therapy started. Significant differences were found in thrombin-antithrombin complex (TAT), prothrombin fragment 1＋2 (F1＋2), and AKIN classification between the two groups. Our findings suggest that TAT and F1＋2 are able to predict the process of circuit coagulation during continuous blood purification therapy.