2019 Volume 10 Issue 2 Pages 115-118
Aim:The relationship between recombinant thrombomodulin (rTM) and the membrane- and blood circuit-related problems of disseminated intravascular coagulation (DIC) patients who received continuous hemodiafiltration using an AN69ST membrane was examined. Methods: Forty-two patients with an acute-stage DIC score ≥4 points and using nafamostat mesilate were divided into an “rTM-administration group” and “non-rTM-administration group”. Then, we investigated the prevalence of: (i) membrane- and blood circuit-related problems; (ii) achievement of the target treatment time. We also investigated the lifetime of the AN69ST membrane. Results: In the rTM-administration group, the prevalence of membrane circuit-related problems was significantly lower, and achievement of the target treatment time was significantly higher, than that of the non-rTM-administration group. Conclusion: Use of rTM as treatment for DIC may be effective for avoiding membrane- and blood circuit-related problems.