Development of a new antithrombogenicity polymer PAN-MPC

Abstract

Hemofilters (polymethylmethacrylate, AN-69ST) used for continuous blood purification therapy against septic shock exhibit high adsorption ability of cytokines due to their negative charges. However, this high adsorption ability, often results in filter clotting with platelets, which severely restricts their long-term treatments. In the study, we explored anti thrombotic materials for more useful hemofilters. The phospholipid structure of 2-methacryloxethyl phosphorylcholine (MPC) is similar to that of the vascular endothelium and a co-polymerized with acrylonitrile (AN) to prepare a polyacrylonitrile (PAN)-MPC polymer. The obtained PAN-MPC polymer was coated on a commercial PAN (AN 69) film. The coated PAN membrane was immersed in rabbit whole blood for 24 h and subsequently analyzed for antithrombotic activity using a scanning electron microscope. The results clearly showed a high antithrombotic activity of the PAN-MPC coated PAN membrane.