Pharmacotherapy during acute blood purification

―circulatory agonist―

Abstract

The administrations of circulatory agonists such as epinephrine and norepinephrine are indispensable in shock state induced by various causes including sepsis. Circulatory agonists must be administered in various amounts depending on the hemodynamic state and the kind of the drug. Some severely ill patients are undergoing hemodialysis due to chronic renal failure, or suffer from acute renal failure or acute exacerbation of chronic renal failure, which need blood purification. When using circulatory agonists in patients with severe renal failure or dialysis, 1) grasp the pharmacokinetics, 2) select hepatic metabolic drugs as much as possible, 3) unavoidable When using renal metabolic drugs, it is necessary to adjust the dose and perform blood levels and ECG regularly.