Polymyxin B immobilized fiber column direct hemoperfusion for severe COVID-19

Abstract

Direct hemoperfusion using a polymyxin B-immobilized polystyrene column (PMX-DHP) is a treatment that selectively adsorbs endotoxins; it is also expected to adsorb a variety of endogenous substances. To evaluate the efficacy and safety of PMX-DHP in oxygen-demanding COVID-19, we previously reported our experience (N=12). PMX-DHP was considered when P/F ratio was less than 300. On day 14 after the first treatment, disease severity decreased in 58.3 ％ of the patients. Subsequently, we have initiated a prospective, multicenter study.