Application of new acute kidney injury biomarkers for initiation of acute blood purification

Abstract

Initiation of acute blood purification is frequently determined by individual clinical judgment based on renal dysfunction and failure of other organs. This study, which retrospectively analyzed 26 AKI patients requiring dialysis, was undertaken to evaluate the new AKI biomarker’s association with acute blood purification initiation. The early initiation group, who needed blood purification during the first day of ICU admission (n=12), showed significantly higher urinary biomarker levels of L-FABP, NAG, and albumin at ICU admission than patients for whom blood purification was performed on day 2 or thereafter (n=14). Adding urinary L-FABP, NAG, and albumin to the clinical model including age, gender, serum creatinine, and APACHE Ⅱ score improved the prediction of early initiation. Although this study was performed retrospectively, these data suggest the potential of these new AKI biomarkers for determining the start of acute blood purification.